摘要
脑缺血后血管生成日益受到关注。脑缺血后，血管生长因子表达增加，促进内皮细胞增生，新生血管形成，从而改善缺血区血液供应，缩小梗死体积。联合应用外源性血管生长因子、干细胞移植、治疗性血管生成促进血管生成主要是通过促进血管生长因子表达实现的。深入研究缺血后血管生成机制，将为缺血性卒中的治疗提供理论依据。
Angiogenesis after cerebral ischemia is of angiogenesis growth factor increases after increasingly receiving attention. The expression cerebral ischemia. It promotes endothelial proliferation and neovascularization, and thus improves blood supply in ischemic regions and decreases the volume of infarction. The combination of exogenous angiogenesis growth factor, stem cell transplantation and therapeutic angiogenesis to promote angiogenesis was mainly achieved by promoting the expression of angiogenesis growth factor. The further study of the mechanism of angiogenesis after ischemia will provide theoretical basis for the treatment of ischemic stroke.
出处
《国际脑血管病杂志》
2008年第5期370-374,共5页
International Journal of Cerebrovascular Diseases
基金
山东省自然科学基金资助项目（编号Y2006C86）
关键词
脑缺血
血管生成
血管生长因子
干细胞移植
cerebral ischernia
angiogenesis
angiogenesis growth factor
stem cell transplantation
