摘要
目的比较来曲唑与克罗米芬在多囊卵巢综合征（PCOS）患者中诱导排卵的疗效。方法将PCOS排卵障碍患者78例分成两组，分别应用来曲唑（5mg，1次／d，连用5d）、克罗米芬（100mg，1次／d，连用5d）。超声监测卵泡发育，当最大卵泡的平均直径≥20mm时，肌注HCG5000IU诱发排卵。观察排卵率、妊娠率、流产率、子宫内膜厚度。结果来曲唑组的排卵率和周期妊娠率与克罗米芬组相似（P〉0．05），但来曲唑组流产率显著低于克罗米芬组（P〈0．05）。来曲唑组在hCG日子宫内膜的厚度显著厚于克罗米芬组（P〈0．01）。结论来曲唑用于PCOS无排卵的不孕症妇女，具有良好的排卵率和妊娠率，流产率显著低于克罗米芬组。
Objective To compare the effects of letrozole and clomiphene citrate （CC） on ovulation induction in polycystis ovarian syndrome （PCOS） patients. Methods Seventy -eight female patients with PCOS caused abnormal ovulation were divided into two groups randomly. One group were treated with letrozole （5 mg,qd ×5 d） and the other group were treated with clomiphene（100 mg,qd ×5 d）. Ultrasound scan was performed to monitor follicle development. When the diameter of the biggest follicle reached 20 mm, 5 000 IU HCG was injected to trigger ovulation. The ovulation rates, pregnancy rates, abortion rates and the thickness of endometrium were compared between the two groups. Results In letrozole group the ovulation rate and pregnancy rate per cycle were similar to those of CC group （ P 〉 0.05 ） , but the abortion rate significantly de- creased （ P 〈 0. 05 ）. The thickness of endometrium on the day of HCG administration in the letrozole group was much thicker than that in CC group （ P 〈 0.01 ）. Conclusion Letrozole can attain good ovulation and pregnancy rates in PCOS women and reduce early abortion rates significantly.
出处
《中国实用医刊》
2008年第12期13-14,共2页
Chinese Journal of Practical Medicine
关键词
来曲唑
克罗米芬
诱导排卵
多囊卵巢综合征
Letrozole
Clomiphene
Ovulation induction
Polycystis ovarian syndrome
