摘要
目的观察注射用阿魏酸钠与贝那普利联合治疗早期糖尿病肾病(DN)和肾功能正常的临床糖尿病肾病(DN)的疗效。方法将84例2型DN患者随机分为对照组(贝那普利)和治疗组(贝那普利+注射用阿魏酸钠)。比较两组治疗前和治疗后9周UAER、Scr和BUN等指标的变化。结果治疗后治疗组和对照组UAER均显著下降(P<0.01,P<0.05),治疗组比对照组下降更为明显(P<0.05);治疗后治疗组Scr显著下降(P<0.05),而对照组则无明显改变;治疗后两组FBG、BUN、MPA、TC和TG均无明显变化。结论注射用阿魏酸钠与贝那普利联合治疗能有效减少早期DN和肾功能正常的临床DN患者的蛋白尿,改善肾功能。
Objective To observe the clinical effecacg of sodiumfetulate and benazepril hydrochlride on early diabetic nephropathy（DN）and clinicals DN. Methods 84 patients of type 2 diabetic patients with DN were randomby divided into control group （benazepril hydrochloride） and treated group（benazcpril hydrochloride and ferul ate sodium）. UARE, ET, Set, and BUN figures were compared between two groups before treatment and nine weeks after treatment. Results UAER had been decreased significantly in both groups（P〈0.01, P〈0.05）, and more significantly in treated group than in control group（P〈0.05）. Set, ET had been decreased significantly in treated group （P〈 0.05）, while no singnificant decrease of Set, ET had been fond incontrol group during the follow-up（P〈0. 05）, Furthermore, no significant decrease of BUN,FBG, MPIA, TC and TG had been found in both groups. Conclusion Diabetic nephropathy and benazepril hydrochloride can ameliorate proteinuria and improve renal function of the patients with early DN and clinical DN of nomal renal function.
出处
《蛇志》
2008年第2期109-110,共2页
Journal of Snake
关键词
注射用阿魏酸钠
贝那普利
糖尿病肾病
尿白蛋白排泄率
肾功能
Sodium ferulate
Benazepril hydrochloride
Nephropathy
Urinaryalbumin excretion rate,Renal function
