摘要
目的：探讨系统性红斑狼疮（SLE）孕妇外周血中的T淋巴细胞亚群的改变。方注：采用流式细胞仪对14例系统性红斑狼疮患者妊娠后（SLE＋NP组）的外周血T淋巴细胞亚群进行检测，并以18例系统性红斑狼疮非妊娠妇女（SLE组），2Z例正常非妊娠妇女（NNP组）作对照。结果：SLE＋NP组的CD3+、CD8+百分率与SLE，NNP组比较元显著性差异，而CD4+的百分率和CD4+／CD8+的比值都明显低于SLE和NNP组（P＜0．01）。结论：妊娠引起部分SLE病情复燃，可能与T细胞亚群的变化有关，CD4+／CD8+比值不失为临床监察SLE患者妊娠后疾病变化的一种有效手段。
Objective: To determine the Change T lymphocyte subsets of peripheral blood in the pregnant womenwith SLE. Methods: The peripheral blood T lymphocyte subsets were detect by FCM in 14 cases of pregnant womencomplicated with SLE, 18 cases of stationary phase SLE, 20 cases of NNP (normal non-pregnant women) were taken ascontrol. Results: The percentage at CD4+ cell decreased significantly in the pregnant women complicated with SLE ascomparing with the other three groups (P<0. 01 ); and the ratio of CD4+ /CD8+ decreased significantly, as withe thegroup of stationary phase SLE and the group NNP. The significantly in the pregnant women complicated with SLE, ascompared with the other three groups. Conctusions: The changes of peripheral T lymphocyte subsets may play an im-portant role in the pregnant women complicated with SLE.
出处
《上海医学》
CAS
CSCD
北大核心
1997年第9期510-511,共2页
Shanghai Medical Journal
