摘要
目的探讨乙肝病毒前S1抗原与乙肝病毒脱氧核糖核酸(HBV-DNA)的相关性以及前S1抗原检测的临床意义。方法检测381例乙肝患者前S1抗原和HBV-DNA定量。结果132例乙肝表面抗原(HBeAg)阳性患者血清中前S1抗原阳性率89.4%,HBV-DNA阳性率91.7%;218例乙肝e抗体(抗-HBe)阳性患者血清中前S1抗原阳性率30.7%,HBV-DNA阳性率27.1%;31例HBeAg和抗-HBe均为阴性,乙肝患者中前S1抗原阳性率38.7%,HBV-DNA阳性率41.9%。前S1抗原与HBV-DNA符合率为92.4%。结论前S1抗原与HBV-DNA符合率较高,可以作为乙肝病毒感染复制的重要指标。
Objective To explore the diagnostcc value of HBV Pre - S1 antigen and correlation with HBV - DNA. Methods For the 381 cases with hepatitis B virus infection, measure HBV Pre - S1 antigen with ELISA and HBV - DNA quantitative with PCR. Results The positive rate of HBV Pre - S1 antigen was 89.4% and HBV - DNA was 91.7% in 132 cases with HbeAg positive . The positive rate of HBV Pre - S1 antigen was30.7% and HBV - DNA was27.1% in 218 eases with anti - Hbe positive. The positive rate of HBV Pre - S1 antigen was38.7% and HBV - DNA was 41.9% in 31 Cases with HbeAg and anti - Hbe were negative, The coincident rate was 92.4% between Pre - S1 antigen and HBV - DNA. Conclusion Bewtten of Pre - S1 antigen and HBV - DNA was highly matched. It can be used as valuabte index for hepatitis B virus infection and replication.
出处
《临床和实验医学杂志》
2008年第6期124-125,共2页
Journal of Clinical and Experimental Medicine
