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补肾方及其拆方对D-氨基半乳糖氨所致小鼠肝损伤的保护作用 被引量:2

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摘要 目的:探讨补肾方抗肝损伤的作用及配伍意义。方法:将补肾方拆为补肾药物组和非补肾药物组,采用D-氨基半乳糖诱导小鼠急性肝损伤模型,观察丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、超氧化物歧化酶(SOD)和丙二醛(MDA)的变化及肝组织病理学的改变。结果:补肾方全方和非补肾药物组能明显降低血清中ALT、AST活性及肝组织中MDA含量,提高SOD活性,改善肝组织病理学。结论:清热和活血类药物是补肾方中抗D-氨基半乳糖所致小鼠肝损伤作用的主要药物。
出处 《吉林中医药》 2008年第6期457-459,共3页 Jilin Journal of Chinese Medicine
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