摘要
目的:研究姜黄素-3脂质体对肝损伤的保护作用及机制。方法:取昆明种小鼠40只,随机分成4组,每组10只:正常对照组、四氯化碳(CCl4)肝损伤模型组、姜黄素-3注射剂组、姜黄素-3脂质体组。采用腹腔注射CCl4致小鼠肝损伤模型,测定动物血清ALT、AST的活性和肝组织脂质过氧化产物丙二醛(MDA)的含量;研究肝组织病理变化。结果:模型组血清ALT、AST及肝组织MDA较正常对照组明显增高,肝组织切片出现肝小叶内炎细胞浸润;治疗组小鼠各生化指标及炎症程度较模型组均明显减轻,脂质体组对肝损伤的药效明显优于注射剂组。结论:姜黄素-3脂质体对小鼠四氯化碳性肝损伤有显著的保护作用,可通过降低肝内脂质的过氧化反应而增加其对肝脏内皮细胞的保护作用。
AIM： To evaluate the therapeutic effects of bisdemethoxycureumin liposome in mice with CCl4-induced acute liver injury model and its mechanism. METHODS： 40 ICR mice were randomly divided into 4 groups： control group, model group, bisdemethoxycurcumin injection group and demethoxycurcurain liposome group （ n = 10）. The liver injury model was made by injecting CCl4 in mouse＇ s abdomen. The activities of ALT, AST in serum, the contents of MDA in liver and ＇the pathological changes of hepatic tissue were investigated. RESYKTS： Compared with those in control group, the serum ALT, AST activities and liver MDA contents of model group were highly increased, but those in bisdemethoxycurcumin injection group and bisdemethoxycurcumin liposome group were reduced significantly. The liver lobules were ameliorated obviously too, especially in bisdemethoxycurcumin liposome group. The pharmacedynamic action of liposome was better than that of the injection. CONCLUSION： Bisdemethoxycureumin liposome has significantly protective effects on CCl4-induced acute chemical liver injury by reducing peroxidation of lipid in endotheliocyte of the liver.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第4期401-405,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
