摘要
目的:研究当归拈痛汤及拆方对类风湿性节炎大鼠血清IL-1β和TNF-α的影响,进一步探讨该药物的作用机制。方法:建立佐剂性关节炎大鼠诱导大鼠类风湿性关节炎模型,观察当归拈痛汤及拆方对实验性大鼠足肿胀的抑制作用,检测血清相关炎性细胞因子IL-1β和TNF-α的水平。结果:当归拈痛汤及各拆方组可显著抑制AA大鼠足跖肿胀及多发性关节炎,抑制AA大鼠过高的炎性细胞因子TNF-α、IL-1分泌,其中拆方1组作用强于拆方2组。结论:当归拈痛汤及拆方在类风湿性关节炎大鼠中可以下调致炎因子IL-1β和TNF-α的水平,提示这可能与该药抑制实验性类风湿性关节炎病情进展密切相关。
Objective ： to study the effect of Dangguiniantong tang and decomposition study on IL - 1B and TNF - α of rheumatoid Arthritis rat, and the mechanism of it. Methods ： take adjuvant induced arthritis rat as experiment model, treat with Dangguiniantong tang and its decomposition, observe the swelling of arthritis, IL - 1B and TNF - α. Results ： Dangguiniantong tang and its decomposition can restrain the swelling of rat arthritis; restrain the express of IL - 1B and TNF - α . the effect of decomposition 1 is better than 2. Conclusion ： Dangguiniantong tang and decomposition can decrease the express of IL- 1B and TNF- α. Of Arthritis rat, it has relation of restrain the development of Rheumatoid arthritis.
出处
《中华中医药学刊》
CAS
2008年第6期1213-1214,共2页
Chinese Archives of Traditional Chinese Medicine
基金
广东省中医药局建设中医药强省科研课题(2007345)
