摘要
采用改良的Ｇｒｉｅｓｓ法，测定了脑缺血再灌流大鼠血清和脑组织中一氧化氮（ＮＯ）代谢产物ＮＯｘ（ＮＯ２＋ＮＯ３）的含量。结果表明，在脑缺血再灌流过程中实验大鼠血清和脑组织中ＮＯｘ含量的变化表现出独特的双峰现象，其第二高峰的出现时间与迟发性神经元损伤的发生相吻合。这提示，ＮＯ在脑缺血再灌流神经损伤中可能具有重要作用。
NO_x (NO_2+NO_3) content,which are nitric oxide (NO) meta,in the serum and brain tissue of rats with after reperfusion following cerebral ischemia was measured with improved Griess method.The results showed that the change of NO_xcontent had a twohumped characteristic,and the second appeared peak consistented with happened delayed neuronal damage.These determined NO is of significance in the neuronal damage after reperfusion following ischemia.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1997年第6期333-335,共3页
Journal of Apoplexy and Nervous Diseases
关键词
一氧化氮
脑缺血
再灌注损伤
动物实验
Nitric oxide Reperfusion following global cerebral ischemia Delayed neuronal damage
