摘要
人的心脏复极化存在性别差异。女性药物诱发的心律失常的发生率远高于男性,而男性房颤和猝死的发生率远高于女性。此外,Brugada综合征、早复极综合征等的发生率也存在性别差异。大量研究结果表明性激素是心肌复极化性别差异的主要影响因素,在一定程度上,性激素通过影响几种主要的离子电流来影响复极化。本文综述了近年来对人类以及几种实验动物(家兔、小鼠、豚鼠)心脏复极时间和离子电流性别差异的研究,及性激素对心脏复极化的直接影响以阐明药物诱发心律失常性别差异的电生理学机制。
There are a number of gender differences in cardiac repolarization. The incidence of drug-induced arrhythmias in women is higher than that in men while the situation of the atrial fibrillation or sudden death is the opposite. Moreover, increasing evidence that gonadal To some extent, sex hormones sex differences exist in Brugada syndrome and early afterdepolarization. There is steroids are important determinants of gender differences in heart repolarization. regulate ion currents to affect repolarization. This review summarized recent advance on sex differences in heart repolarization and ion currents in human as well as in animals （rabbit, mouse and guinea pig） and the direct effects of sex hormones on repolarization in order to elucidate the electrophysiological mechanisms underlying the gender-related differences in drug-induced arrhythmias.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2008年第5期359-364,共6页
Chinese Journal of New Drugs and Clinical Remedies
关键词
心律失常
激素替代疗法
钾通道
钙通道
性别差异
复极化
arrhythmia
hormone replacement therapy
potassium channels
calcium channels
gender difference
repolarization
