期刊文献+

普罗帕酮试验引起Brugada综合征心室颤动(附一例报告) 被引量:7

The Propafenone Challenge Provoked Ventricular Fibrillation in A Patient With Brugada Syndrome.
下载PDF
导出
摘要 探索普罗帕酮试验在Brugada综合征中的作用及安全性。患者有家族性夜间猝死史 ,近 1 9个月来反复发作性夜间晕厥5次 ,两次猝死未遂 ,一次记录到的心电图为心室颤动 (VF) ,其超声心动图、冠状动脉造影、左右心室造影正常 ,电生理检查心脏传导系统功能正常 ,右心室程序电刺激可诱发VF ,诊断不明。静脉用普罗帕酮 2mg/kg后 30min出现典型Brugada综合征心电图改变 ,并诱发VF。结论 :普罗帕酮可作为诊断Brugada综合征的工具 。 To identify the diagnostic impact and safety of the propafenone in Brugada syndrome. A patient with the family history of nocturnal sudden cardiac death experienced five times syncope and two times aborted sudden cardiac death during last 19 months. The ventricular fibrillation (VF) was documented in one syncope episode. His coronary arteries were normal by the angiogram. The echocardiography and ventriculography showed normal structurally heart. The AH and HV intervals was normal. The VF was induced by the programmed stimulation in the right ventricular apex. The diagnosis could not be made from his history and above work ups. The propafenone challenge (2 mg/kg) demonstrated the typical Brugada ECG change and provoked the VF in 30 minutes after intravenous.Conclusions: The propafenone challenge could unmask the concealed Brugada syndrome. Proarrhythmic effects of the drug should be cautious.
出处 《中国心脏起搏与心电生理杂志》 2004年第3期190-191,共2页 Chinese Journal of Cardiac Pacing and Electrophysiology
基金 南京医科大学创新基金 (CX2 0 0 3 0 15 )
关键词 心血管病学 BRUGADA综合征 心室颤动 普罗帕酮 Cardiology Brugada syndrome Ventricular fibrillation Propafenone
  • 相关文献

参考文献7

  • 1Brugada P, Brugada J. Right bundle block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report[J]. J Am Coll Cardiol, 1992,20(6):1 391 被引量:1
  • 2Miyazaki T, Mitamura H, Miyoshi S et al. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome[J]. J Am Coll Cardiol, 1996,27(5):1 061 被引量:1
  • 3Yan CX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation[J]. Circulation, 1999,100(15):1 660 被引量:1
  • 4Wichter T, Matheja P, Eckardt L et al. Cardiac autonomic dysfunction in Brugada syndrome[J]. Circulation, 2002,105(6):702 被引量:1
  • 5Brugada R, Brugada J, Antzelevitch C, et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal heart[J]. Circulation, 2000,101(5);510 被引量:1
  • 6Wilde AAM, Antzelevitch C, Borggrefe M, et al. Proposed diagnostic criteria for the brugada syndrome consensus report[J]. Circulation, 2002,106:2 514 被引量:1
  • 7Rolf S, Bruns HJ, Wichter T, et al. The ajmaline challenge in Brugada syndrome: Diagnostic impact, safety, and recommended protocol[J]. Eur Heart J, 2003,24:1 104 被引量:1

同被引文献149

引证文献7

二级引证文献38

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部