摘要
目的:观察吡格列酮对已使用较大剂量胰岛素而血糖控制仍不满意的2型糖尿病的疗效观察。方法:将80例胰岛素治疗日剂量大于50单位的2型糖尿病患者随机分为两组,观察组在胰岛素基础上加用吡格列酮8 mg,qd,对照组继续胰岛素治疗,治疗16周,治疗前后进行空腹血糖、餐后血糖、糖化血红蛋白、空腹胰岛素(Flns)、C肽水平及胰岛素日剂量的测定。结果:观察组能显著降低患者血糖和糖化血红蛋白,降低Flns、C肽水平,胰岛素日剂量也明显减少(P<0.01),且无肝肾功能损害发生。结论:吡格列酮联合胰岛素治疗能长期有效地控制血糖,并减少胰岛素用量、减轻胰岛素抵抗。
OBJECTIVE： To observe the curative efficacy of Pioglitazone for patients whose blood sugar level failed to be downregulated even if with the treatment of high dose of isulin. MEHTODS： A total of 80 patients with type 2 diabetes treated with isulin at a daily dose of more than 50 units were randomly assigned to receive insulin alone （control group） or insulin in combination with Pioglitazone 8mg qd （trial group） for 16 weeks. The levels of blood- fasting sugar, postprandial blood sugar, glycosylated hemoglobin, blood- fasting insulin （Flns） and C peptide, and daily dose of insulin before and after treatment were measured. RESULTS： In the trial group, the levels of blood sugar, glycosylated hemoglobin, Flns, C peptide and daily dose of insulin were significantly reduced （ P 〈 0.01 ）, and no kidney lesion was noted. CONCLUSION ： Used in combination with insuliln, Pioglitazone could effectively control the blood sugar, reduce the dosage of insulin and lessen the insulin resistance.
出处
《中国医院用药评价与分析》
2008年第5期376-377,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
