摘要
目的研究芪蛭胶囊对四氯化碳(CCl4)所致小鼠急性肝损伤的保护作用。方法采用0.2%CCl4液体石蜡灌胃制作CCl4小鼠急性肝损伤模型。通过检测血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子-α(TNF-α)、总蛋白(TP)和白蛋白(ALB)水平,探讨芪蛭胶囊对CCl4致小鼠急性肝损伤的保护作用。结果模型组与空白组比较,血清ALT、AST明显增高(P<0.01);芪蛭胶囊组与模型组比较,血清ALT、AST、TNF-α明显降低(P<0.01)。结论芪蛭胶囊对CCl4所致小鼠急性肝损伤有一定的保护作用。
Objective To investigate the protective effects of Qizhi capsule against acute hepatic injury induced by CCl4 in mice.Methods Acute hepatic injury model was induced by intragastric administration of 0.2% CCl4 paroleine.To explore the roles of Qizhi capsule against acute hepatic injury induced by CCl4 in mice,by observe the change of blood serum alanine aminotransferase（ALT）、aspartate aminotransferase（AST）、tumor necrosis factor-α（TNF-α）、total protein（TP）and albumin（ALB） Results The serum ALT,AST,TNF-α in mice in model group were increased significantly compared with control group（P〈0.01）.The serum ALT,AST,TNF-α in Qizhi capsule group were decreased significantly compared with model group（P〈0.01）.Conclusion Qizhi capsule have an extended protection effect to the acute hepatic injury induced by CCl4 in mice.
出处
《青海医学院学报》
CAS
2008年第1期33-35,共3页
Journal of Qinghai Medical College
关键词
芪蛭胶囊
四氯化碳
急性肝损伤
实验研究
Qizhi capsule Carbon tetrachloride Acute hepatic injury Experimental study
