摘要
目的探讨普伐他汀、阿托伐他汀对不稳定型心绞痛(UA)患者C反应蛋白(CRP)和白介素-6(IL-6)的影响。方法将136例不稳定型心绞痛患者随机分为普伐他汀组(46例)、阿托伐他汀组(46例)、常规治疗组(44例),测定治疗前,治疗8周后CRP、IL-6、血脂。结果普伐他汀组及阿托伐他汀组治疗前后CRP、IL-6、血脂均有显著下降(P<0.05),且阿托伐他汀组较普伐他汀组血脂下降显著(P<0.05),而常规治疗组CRP、IL-6、血脂无明显变化;阿托伐他汀组、普伐他汀组治疗前后血脂下降与CRP、IL-6下降没有相关性(P>0.05)。结论普伐他汀、阿托伐他汀均可降低UA患者CRP、IL-6、血脂,均具有抗炎作用,其抗炎作用部分不依赖降脂作用。
Objective To evaluate the effects of pravastatin and atorvastatin on serum C reactive protein and IL 6 in patients with unstable angina. Methods One hundred and thirty six patients were randomly assigned into three groups： placebo therapy group, pravastatin group, and atorvastatin group. All patients received conventional drug and supportive therapy, in addition, the atorvastatin group received additional atorvastatin （10mg/d） for 8 w and the pravastatin group received additional pravastatin （20mg/d） for 8 w. Then all the patients＇ serum C reactive protein, intedeukin 6 and blood lipids were measured just before and after therapy. Results Serum C - reactive protein, interleukin 6, and lipid levels were significantly reduced in pravastatin and atorvastatin groups as compared with those of the placebo group （P〈 0.05）, and the blood lipid level reduction in atorvastation group was significantly more than that of the pravastatin group （P〈 0.05）. The reduction of serum C-reactive protein and interleukin - 6 levels showed no correlation with the reduced lipid levels both in pravastatin group and atorvastatin group before and after treatment （P 〉0.05）. Conclusion Pravastatin and atorvastatin potentiates the decline of serum C reactive protein, interleukin 6, and lipid levels in patients with unstable angina, their effects do not depend on the reduction of lipid level.
出处
《实用预防医学》
CAS
2008年第2期508-509,共2页
Practical Preventive Medicine
