摘要
目的了解抗肿瘤药物引起的不良反应,为深入开展药品不良反应监测工作提供依据。方法对我院2005年2月至2007年9月收集的95例抗肿瘤药物的不良反应报告进行回顾性分析。结果静脉滴注给药引发的不良反应为71例,占74.74%;阿糖胞苷引发的不良反应最多见,有42例,占44.21%;神经系统损害最常见;重度药品不良反应14例,占14.74%,表现为速发型过敏反应。结论临床应重视抗肿瘤药物引起的不良反应,须定期监测与报告,其可为临床治疗提供参考资料,减少或避免药品不良反应的发生。
Objective To investigate the adverse drug reaction （ADR） induced by antineoplastics, and provide bases for deep ADR monitoring. Methods 95 ADR reports collected between February 2005 and September 2007 in our hospital have been analyzed retrospectively. Results In the total ADR cases, 71 ADR（74.74%） were caused thorough intravenous route of administration. 42 ADR （44.21%） were induced by Cytarabine. And the nervous system lesions is primary. 14 severe ADR（14.74%） manifested as immediate allergic reaction. Conclusion It is important to pay close attention to the ADR induced by antineoplastics. Regular monitoring and reporting is needed so as to lessen or avoid the occurrence of ADR.
出处
《中国药物警戒》
2008年第2期104-107,118,共5页
Chinese Journal of Pharmacovigilance
关键词
抗肿瘤药物
药品不良反应
监测
antineoplastics
adverse drug reaction
monitoring
