摘要
目的:探讨脑梗塞患者血致动脉硬化指数(AIP)、非高密度脂蛋白胆固醇(non-HDL-C)水平及临床意义。方法:随机选择207例脑梗塞患者,并分为不同颈总动脉内中膜厚度(IMT)组;颈动脉硬化组和非颈动脉硬化组;体重指数(BMI)正常组和BMI升高组;高血压组和血压正常组。均在治疗前测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及测量身高、体重、血压等,计算出AIP及non-HDL-C;另取101例健康体检者为正常对照,进行统计学处理。结果:①与正常对照组相比较,脑梗塞患者呈现出高TG、低HDL-C及AIP值明显升高;②脑梗塞患者non-HDL-C等水平随着IMT的增加而升高,而AIP没有统计学差异;③颈动脉硬化组、高血压组、BMI增高组的non-HDL-C、AIP水平明显高于非颈动脉硬化组、血压正常组、BMI正常组。结论:脑梗塞患者AIP、non-HDL-C水平明显升高;伴颈动脉硬化、高血压、高BMI时升高更显著;故两者对脑梗塞的治疗、预后等具有重要临床意义。
Objective：To analyze the concentration and significance of non - high density lipoprotein cholesterol （ non - HDL -C） and atherogenic index of plasma （AIP） from patients with cerebral infarction. Methods：The levels of triglyceride （TG）, total cholesterol （ TC ）, high density lipopro - tein cholesterol （ HDL - C ）, low density lipoprotein cholesterol （ LDL - C ） were determined in 207 patients with cerebral infarction and in 101 healthy individuals as normal control group. The patients with cerebral infarction were divided into carotid arteriosclerosis group and non -carotid arteriosclerosis group, high blood pressure group and normotension group, body mass index（BMI） heighten group and normal BMI group. Results：The levels of TG, TC, non - HDL - C, LDL - C, HDL - C and AIP increased significantly in patients with cerebral infarction. There was significant difference of the levels of non - HDL - C in different IMT groups, and the levels of non - HDL - C increased with IMT. The levels of non - HDL- C and AIP increased significantly in cerebral infarction patients with carotid arteriosclerosis group, high blood pressure group, BMI heighten group. Conclusion： Non - HDL - C and AIP increase significantly in patients with cerebral infarction, which is stepped up extremely with carotid arteriosclerosis, high blood pressure, BMI heightening.
出处
《中国卫生检验杂志》
CAS
2008年第3期473-474,490,共3页
Chinese Journal of Health Laboratory Technology
关键词
脑梗塞
血浆致动脉硬化指数
低密度脂蛋白胆固醇
Cerebral infarction
Non -high density lipoprotein cholesterol
Atherogenic index of plasma
