摘要
目的建立稳定可靠的大鼠皮肤撕脱伤模型。方法雄性sD大鼠30只，随机分为轴型皮瓣（9em×3cm）对照组及牵拉组，任意皮瓣（6em×4cm）对照组及牵拉组。轴型皮瓣施予牵拉力6kg，任意皮瓣施予牵拉力8kg，牵拉时间分别为8秒和12秒。观察创面收缩及皮瓣坏死情况。结果术后第7天，牵拉组较对照组创面收缩率明显增加（P〈0．05）；术后第14天，牵拉组创面收缩率较术后第7天时增加近1倍（P〈0．01），但牵拉8秒组与12秒组间差异无统计学意义。术后第7天，牵拉组皮瓣100％发生部分或大部坏死。轴型皮瓣牵拉8秒导致38％～77％面积坏死，牵拉12秒导致40％～80％面积坏死；任意皮瓣牵拉8秒导致17％～40％面积坏死，牵拉12秒导致24％～43％面积坏死。结论应用大鼠制作皮肤撕脱伤模型是可行的。
Objective To create a stable and reliable model of skin avulsion in rats. Methods 30 male, SD rats were randomly divided into axial pattern skin flap （9 cm× 3 cm） group and random pattern skin flap group（6 cm × 4 cm）, each having the control groups and avulsion groups. Flaps were subjected to avulsion force of 6 kg in axial pattern skin flaps or 8 kg in random pattern skin flaps, and the lasting time was 8 s or 12 s, respectively. Retraction of wounds and necrosis of skin flaps were observed. Results There was more significant wound retraction in avulsion groups than that in controi groups on post-operation day 7 （ P 〈 0.05）. The proportion of the wound retraction increased by 1 fold in avulsion groups on post-operation day 14 as compared to post-operation day 7 （ P 〈 0.01 ）. Interestingly, necrosis of partial or most of skin flaps was observed in all animals of avulsion groups, while slight necrosis happened in one of six in control animals. The necrosis area of flaps was 38% - 77% when avulsed for 8 s, and was 40% - 80% when avulsed for 12 s in axial pattern skin flaps. However, the necrosis area in random pattern skin flaps was smaller than that in axial pattern skin flaps, from 17% - 40% when avulsed for 8 s to 24% - 43% when avulsed for 12 s. Conclusions It might be possible to creat animal model of skin avulsion injuries with rats.
出处
《中华整形外科杂志》
CAS
CSCD
北大核心
2008年第3期212-215,共4页
Chinese Journal of Plastic Surgery
关键词
SD大鼠
模型
动物
外科皮瓣
撕脱损伤
Sprague-Dawley rats
Models,animal
Surgical flaps
Avulsion injuries
