摘要
脂蛋白相关磷脂酶A2主要由巨噬细胞和淋巴细胞产生,大部分与低密度脂蛋白结合,能水解低密度脂蛋白上的氧化磷脂,产生溶血卵磷脂和氧化游离脂肪酸,促进炎症和动脉粥样硬化的发生发展,可作为冠心病危险的独立预测因子。
Lipoprotein-associated phospholipase A2 （ Lp-PLA2 ） is secreted mainly by macrophages and lymphocytes. The enzyme is predominantly bound to low-density lipoprotein cholesterol particles in humans,its activity produces lysophosphatidylcholine and non-esterified fatty acids that promote inflammatory processes present at every stage of atherogenesis. Lp-PLA2 is an independent risk predictor of coronary heart disease.
出处
《心血管病学进展》
CAS
2008年第3期422-425,共4页
Advances in Cardiovascular Diseases
关键词
脂蛋白相关磷脂酶A2
冠心病
动脉粥样硬化
预测因子
lipoprotein-assoeiated phospholipase As
coronary heart disease
atherosclerosis
predictor
