摘要
目的探讨胃癌组织中胸苷酸合成酶(TS)的表达及其与临床病理因素的关系。方法采用免疫组织化学染色的方法(S-P法)检测了48例胃癌组织中TS基因表达情况,并用SPSS10.0统计软件分析其与临床病理因素的关系。结果48例胃癌组织中TS基因表达的阳性率为52.1%(25/48);TS的表达与肿瘤分化程度、浸润深度、淋巴结转移与否及临床病理分期密切相关(P<0.05)。结论胃癌组织中TS表达水平可能是胃癌患者1个重要的预后指标。
Objective To evaluate the expression of thymidylate synthase and its relationship with clinicopathologieal parameters in advanced gastric carcinoma. Methods Expression. of thymidylate synthase was detected by immuuohistochemistry （S-P method） in 48 gastric carcinoma tissues. Its relationship with clinicopathological parameters was analyzed by SPSSIO. 0 sta- tistical software. Results The positive rate of thymidylate synthase expression was 52. 1% （ 25/48 ）. TS expression was significantly correlated with the degree of tumor differentiation, depth of invasion,lymph node metastasis and clinical stage （ P 〈0. 05）. Conclusion The expression of TS may be one of the important prognostic factors for gastric cancer.
出处
《实用癌症杂志》
2008年第3期240-241,共2页
The Practical Journal of Cancer
关键词
胃肿瘤
胸苷酸合成酶
免疫组织化学
Stomach neoplasms
Thymidylate synthase
Immunohistochemistry
