摘要
目的:探讨Survivin蛋白和Fas蛋白在膀胱移行细胞癌中的表达和意义。方法:用免疫组化S-P法检测62例膀胱移行细胞癌组织及10例正常膀胱粘膜组织中Survivin蛋白和Fas蛋白的表达。结果:10例正常膀胱粘膜组织中Fas蛋白表达均为阳性,Survivin蛋白表达均为阴性;Fas在膀胱移行细胞癌中阳性表达率为46.77%(29/62),肿瘤不同分级中随恶性程度的增高,表达减少,Ⅰ级与Ⅲ级比较,差异有显著性意义(P<0.05),不同临床分期中随分期的增高,表达减少,Tis^T1与T2~T4比较,差异无显著性意义(P>0.05);Survivin蛋白在膀胱移行细胞癌中阳性表达率为56.5%(35/62),肿瘤不同分级中随恶性程度的增高,表达增高(P<0.05),不同临床分期中随分期的增高,表达增高,差异有显著性意义(P<0.05);Fas蛋白和Survivin蛋白表达负相关(P<0.05)。结论:Survivin蛋白和Fas蛋白在膀胱移行细胞癌的发生、发展过程中起着重要的作用,其异常表达可作为膀胱移行细胞癌肿瘤标志物。
Objective：To investigate the expression of survivin and Fas in bladder transitional cell carcinoma（TCC） and their clinical significance. Methods：The expressions of survivin and Fas were examined with S - P immunohistochemistry in 10 subjects with normal urinary bladder tissues and 62 cases of bladder TCC. The results of both groups were compared each other. Results： All normal urinary bladder tissues showed positive staining of Fas protein and negative staining of survivin. The positive rate of Fas in 62 cases of bladder TCC was 46.77%. The difference of positive rate between grade Ⅰ and grade Ⅲ cases was significant（P〈0.05） and between Tis～T1 and T2～T4 cases showed a decreased trend but without significance（P〉0. 05）. The positive rate of survivin in 62 cases of bladder TCC was 56.5%. The difference of positive rate between grade I and Ⅲ grade cases was significant（P〈0.05） and between Tis～T1 and T2～T4 was also significant（P〈0. 05）. The expression of survivin protein was reversely correlated with that of Fas protein （P〈0. 05）. Conclusion：The abnormal expression of Fas protein and survivin protein play an important role in the occurrence and progress of bladder TCC and it can be regarded as a useful diagnostic marker for bladder TCC.
出处
《西南国防医药》
CAS
2008年第3期349-351,共3页
Medical Journal of National Defending Forces in Southwest China
