摘要
采用MnCl2滴注大鼠鼻腔,分析嗅球截面上锰、钙等分布及其关联性,探讨锰示踪激活钙的神经通路机理。结果表明:嗅球中锰、钙分别比滴鼻前增加54%和85%,呈现出外周各层高,中间嗅室、室管膜内低的盆地状关联分布。钙的增长区域比锰更深,达颗粒细胞层。嗅球腹外侧的锰及腹侧、外旁侧各层的钙增长显著;内侧各层的锰、钙虽多但变化小,各区神经密度差异影响Mn2+、Ca2+的传入与分布,说明Mn2+跨神经元传递时会损失。特定区域缺乏结合Mn2+的投射神经导致Mn2+、Ca2+含量低、变化小。Mn2+通过Ca2+通道和微管运输进入嗅神经细胞后抑制Ca2+外流,并跨突触传递到嗅球外周各层神经是Mn2+、Ca2+关联和增加的部分机制。
A study was conducted to examine the Mn and Ca correlation in olfactory bulb （OB） and stimulation of Ca by Mn in neurons of rats. The contents of Mn and Ca were measured in certain sections of OB after MnCl2 solution piptted into nasal cavities. The results indicated that both Mn and Ca increased significantly, by 54% and 85 % respectively, with their distributions being higher in periphery and lower in center. Ca distribution area was wider than that of Mn. Mn in external side and the Ca in ventral side enhanced remarkably, whereas little change observed in inner side. Neuron types and its density in different parts might play its role as the lack of Mn^2＋ receptor cells or Mn^2＋ projecting neurons in regions of olfactory epithelium and OB resulted in the absences of the elements in some parts of OB. Entering receptor cells in olfactory epithelium via Ca^2＋channels and then being imbibed by the microtubule-dependent transporting system along with inhibiting Ca^2＋ effused out from neurons may contribute to Mn^2＋distribution associated with Ca^2＋.
出处
《扬州大学学报（农业与生命科学版）》
CAS
CSCD
北大核心
2008年第1期6-10,共5页
Journal of Yangzhou University：Agricultural and Life Science Edition
基金
江苏省自然科学基金资助项目(BK2006560)
南京农业大学生命科学实验中心开放课题基金项目(680810150)
关键词
嗅球
锰
钙
CA^2+通道
微管运输
olfactory bulb
Mn
Ca
Ca^2＋ channel
microtubule dependent transport system
