摘要
目的:建立以液相色谱-串联质谱法快速分析伏立康唑的碱降解产物的方法。方法:借助色谱-串联质谱技术,比较并分析伏立康唑对照品和其碱降解产物的相对分子质量、碎片、光谱特征等信息。结果:伏立康唑与其降解产物能有效分离,2个主要降解产物分别为去4-乙基-5-氟嘧啶的同分异构体。结论:该方法快速、灵敏、专属性强,可用于推测伏立康唑降解产物的结构。
OBJECTIVE： To establish an LC - MS - MS method for the rapid analysis of the degradation compounds of vorionazole. METHODS： The degradation compounds and the control substance of vorionazole were compared in respect of relative molecular mass, fragments, spectra characteristics using LC- MS- MS technology. RESULTS： Vorionazole and its degradation compounds could be effectively isolated. The two main degradation compounds were the isomers of 4-ethyl- 5- fluoropyrimidine. CONCLUSION： The analytic method is rapid, sensitive, and specific, and it can be applied to predicate the structure of the degradation compounds of vorionazole.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第13期1007-1009,共3页
China Pharmacy
基金
国家自然科学基金资助项目(30600818,30600823)
