摘要
目的:探讨调脂治疗对不同年龄组新诊2型糖尿病(T2DM)亚临床动脉粥样硬化(AS)的影响。方法:采用前瞻性、病例对照研究设计,120例(106例完成随访)无AS的新诊T2DM患者根据年龄被分为老年组与中年组,老年组中再随机分为老年A组(26例,强化降糖+降压)、老年B组(26例,强化降糖+降压+调脂治疗),中年组再随机分为C组(34例,强化降糖+降压)、D组(34例,强化降糖+降压+调脂治疗)。干预72周后,随访观察4组亚临床AS的发生情况。结果:A组和B组的亚临床AS发生率无明显差异,D组的AS发生率显著低于A、B、C组(P<0.05)。结论:对于早期的中年T2DM患者,在强化降糖、降压、治疗外,加用他汀类调脂药物相对于老年患者可获得较明显的预防AS效果。
Objective： To investigate the effects of blood lipid control on sub clinical atherosclerosis （AS） in newly diagnosed type 2 diabetic （TzDM） patients. Methods： A prospective and ease-controlled study was used. One hundred and twenty newly diagnosed T2DM patients without AS were divided into old-aged group and middle-aged group according to their age; and old-aged group divided into group A （intensive blood glucose and blood pressure control）, group B （group A treatment plus blood lipid controls） ; middle-aged group divided into group C （intensive blood glucose and blood pressure control）, group D （group C treatment plus blood lipid controls）. The incidence of sub clinical AS at seventy-two weeks of intervention was compared among four groups. Results： In group A and B, the morbidity of sub clinical AS was no significantly difference. The morbidity of sub clinical AS of group D was significantly lower than those of group A, B and C （P〈0. 05）. Conclusion： Control blood lipid added to intensive blood glucose and blood pressure intervention may produce more effective to reduce the incidence of sub clinical AS in newly diagnosed middle-aged type 2 diabetic patients.
出处
《心血管康复医学杂志》
CAS
2008年第2期160-162,122,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
2型糖尿病
高脂血症
动脉粥样硬化
Diabetes mellitus, type 2
Hyperlipoidemia
Atheroselerosis
