摘要
目的:调查北京地区乙型肝炎病毒(HBV)基因型及基因亚型的分布情况和临床意义。方法:应用型特异性引物聚合酶链反应法,对北京地区850份HBV感染者血清进行基因型、基因亚型检测,包括慢性乙型肝炎660例,肝硬化85例,肝癌105例。结果:B型、C型、BC混合型分布在不同类型乙肝病毒感染者中分布差异有显著性,肝硬化,肝癌患者C型所占比例明显高于慢性乙型肝炎患者。HBeAg阳性和阴性感染者中,HBV基因型分布差异无显著性。慢性肝炎、肝硬化及肝癌组中,均以C2和Ba亚型占优势。结论:在北京地区HBV感染者中,以Ba和C2亚型为主,C基因型感染者更易于发展为肝硬化、肝癌。
Objective：To investigate the distribution and the clinical significance of genotypes and subtypes of HBV in Beijing. Methods ： We used type specific primers and polymerase chain reaction to detect genotypes and subtypes of HBV in 850 patients with HBV-infected from Beijing, including 660 chronic hepatitis （CH）, 85 liver cirrhosis （LC）, and 105 hepatocellular carcinoma （HCC）. Results ：The genotypes and subtypes distribution of HBV had significant differences in the various clinical types of HBV infection, and the genotype C was predominant among the patients with LC and HCC. Genotypes showed no significant differences in patients with positive or negative HBeAg. Conclusion：Subtype C2 and ga are predominant among the patients with CH, LC and HCC. Subtype Ba inhabits the genotype B and subtype C2 predominates genotype C in Beijing. Genotype C may be associated with the development of LC and HCC.
出处
《中国误诊学杂志》
CAS
2008年第15期3537-3539,共3页
Chinese Journal of Misdiagnostics
