摘要
乙型肝炎病毒(HBV)是嗜肝DNA病毒的一种,其基因组至少含有4个开放读码框,分别为编码外膜蛋白的S基因区、编码核衣壳蛋白的C基因区、编码P蛋白的P基因区及编码X蛋白的X基因区。此外,还发现了两个新的区域,前-前-S区和前-X区。各结构区在病毒的复制、感染、致癌等方面发挥重要作用,文章就其结构和功能的研究进展作一综述。
Hepatitis B virus （HBV） is a member of the hepadnaviruses family, its genome comprises four open reading frames（ORF） at least named as the regions of S, C, P and X, respectively encoding envelope （HBs Ags）, the viral core （HBc Ag）, polymerase/reverse-transcriptase （pol）, and HBx polypeptides. Besides, new ORF named pre-pre-S and pre-X were found in some studies. All regions play important roles in replication, infection, carcinogenesis of HBV respectively. This review focuses on some advances about the structure and function of open reading frame.
出处
《国际消化病杂志》
CAS
2008年第2期114-116,共3页
International Journal of Digestive Diseases
基金
浙江省自然科学基金项目(y205445)
