摘要
IFN是一种具有广谱抗病毒、抗肿瘤、抑制细胞增殖及免疫调节作用的活性蛋白,至少可分为α、β、δ、ε、κ、ω、τ和limitin八种,分子质量约为18.5 kDa,包括4个保守的半胱氨酸,形成2对分子内二硫键。IFN-α/βR是IFN-α和IFN-β共同结合受体,包括IFNAR1和IFNAR2,IFNAR1仅有1个亚单位,IFNAR2由3个亚单位组成。IFN与位于细胞膜上的特异性受体结合,主要经JAK-STAT途径介导信号传导,不仅能通过PKR、2-′5′OAS、Mx和ADAR1等途径发挥抗病毒作用,还能通过对淋巴细胞和巨噬细胞的调节以及诱导MHC分子表达等途径发挥直接或间接的免疫调节作用。
IFN,a kind of broad-spectrum anti-viral active protein of 18.5 kDa,including four conserved cysteines which froms two pairs of intramolecular disulfide bonds,can be divided into at least 8 types α,β,δ,ε,κ,ω,τ and limitin.It has better effects of anti-tumor,inhibition of cell proliferation and immune regulation.IFN-α/β receptor,the co-receptor binding to IFN-α and IFN-β,includes IFNAR1 and IFNAR2.IFNAR1 has only one subunit,while IFNAR2 is composed of three sub-units.As IFN combines with its specific receptors on the cell membrane,the main pathway of JAK-STAT signal transduction can be activated.On the basis of above pathway,the antiviral effects of IFN can be demonstrated through multiple ways,such as PKR,2＇-5＇OAS,Mx,and ADAR1.The direct or indirect immune regulatory roles of IFN can be played via the regulation of lymphocytes and macrophages and the expression of MHC molecules.
出处
《中国微生态学杂志》
CAS
CSCD
2011年第4期375-380,383,共7页
Chinese Journal of Microecology
基金
安徽省自然科学基金(090413138)
安徽省教育厅自然基金重点项目(KJ2010A086
KJ2009A032
KJ2007A019)
关键词
IFN
信号转导
结构
功能
IFN
Signal transduction
Structure
Function
