摘要
目的:研究非甾体抗炎药(NSAIDs)致老年人相关性胃十二指肠溃疡并发出血的临床特点。方法:调查我院2006年1月至2007年12月期间经胃镜检查确诊为胃十二指肠溃疡并出血的60岁以上住院患者,根据入院前1周内有无服用NSAIDs将患者分为NSAIDs组(46例)及非NSAIDs组(38例),对两组病人的临床资料进行分析比较。结果:老年人服用NSAIDs所致的溃疡出血发病率持续上升,其占同期老年人消化性溃疡并出血的30.3%(46/152),与国内2006年文献报道27.17%接近,高于国内2001年文献报道16.51%;其起病隐匿,多以出血为首发症状,就诊时多已存在不同程度的贫血,内镜下复合溃疡、多发溃疡多见,病变损害范围更广泛,导致其病情较非NSAIDs组严重;而NSAIDs组幽门螺杆菌(Hp)阳性者和Hp阴性者的溃疡发生率无明显差异。结论:应加强对老年人NSAIDs相关性胃十二指肠溃疡并发出血临床特点的认识,采取适宜策略降低NSAIDs的不良反应。
Objective： To study the clinical characteristics of non - steroidal anti - inflammatory drugs （ NSAIDs） associated gastroduodenal ulcer bleeding in the aged. Method： Patients who were hopitalized in our ward because of gastroduodenal bleeding from Jan. 2006 to Dec. 2007 were divided into NSAIDs group and non-NSAIDs group on whether consumed NSAIDs within 10 days previous to onset bleeding and the age（≥60 years）. Result： The morbidity rates continue to rise of non-steroidal anti-inflammatory drugs associated gastroduodenal ulcer bleeding in the aged. It is 30.3% （46/152） of the total aged cases of non-steroidal anti-inflammatory drugs associated gastroduodenal ulcer bleeding. The morbidity rates is approximative to that reported in the literature of 2006（27.17% ）, and higher than that reported in the literature of 2001 （16.51% ）. The onset of the disease is latent, the hemorrhage symptoms and various degree of anemia as primary symptom in this patients. There was more complex ulcer and more ulcer in the NSAIDs group than those in non-NSAIDs group, it leads to more severe than non - NSAIDs group. In the NSAIDs group, the incidence of gastroduodenal ulcer in helicobacter pylori （ Hp ） positive and helicobacter negative was no significant difference. Conclusion： The clinical characteristics of NSAIDs associated gastroduodenal bleeding should be better understood so as to decrease the occurrence of NSAIDs ulcer and its complication.
出处
《河北医学》
CAS
2008年第4期383-386,共4页
Hebei Medicine
关键词
老年人
非甾体抗炎药
胃十二指肠溃疡
Aged
Non -steroidal anti -inflammatory drugs
Gastroduodenal ulcer
