摘要
目的观察2型糖尿病(DM2)患者不同尿白蛋白排泄率尿单核细胞趋化蛋白-1(MCP-1)含量变化及临床意义。方法59例糖尿病患者根据尿蛋白排泄量(UAE)分成3组,分别测定其尿MCP-1的水平及血肌酐(SCr)、尿素氮(BUN)、血脂、血压、糖化血红蛋白(HbA1c),并与27例年龄、性别、体质指数(BMI)与观察组相匹配的对照组相比较。结果2型DM患者尿MCP-1水平明显高于对照组,在正常蛋白尿组中尿MCP-1就已经开始升高(P<0.05),微量蛋白尿组及临床蛋白尿组尿MCP-1水平明显高于正常蛋白尿组,且临床蛋白尿组尿MCP-1水平显著高于微量蛋白尿组;2型DM患者尿MCP-1水平与UAE、收缩压、舒张压、LDL-C、CHO呈显著正相关(P<0.05),而与HbA1c、HDL-C、TG无统计学相关性。结论MCP-1可能参与了糖尿病肾病(diabetic nephropathy,DN)的发生发展,检测尿中MCP-1含量对于早期DN的诊断及其干预有重要意义。
Objective To investigate the levels and the clinical significance of urinary monocyte chemoattractant protein-1 （uMCP-1 ） at different stage of diabetic nephropathy（DN）. Methods Fifty-nine cases with diabetes mellitus（DM） were divided into three groups according to urine albumin excetion（UAE）：normal albuminuria group;microalbuminuria group and clinical albuminuria group. The levels of uMCP-1, SCr,BUN,serum lipid concentration,blood pressure and HbAlc were measured,and twenty-seven normal control subjects were measured at the same time. Results Compared with normal control,levels of uMCP-1 in DM were significantly high. Compared with normal albuminuria group,levels of uMCP-1 in microalbuminuria group and clinical albuminuria group were significantly high. Level of uMCP-1 in clinical albuminutia group was higher than that of microalbuminuria group. Level of uMCP-1 was positively correlated with UAE,systolic blood pressure （SBP） ,diastolic blood pressure （DBP）,CHO and LDL-C in DM patients,while had no significant correlation with HbA1c,TG and HDL-C. Conclusion MCP-1 is implicated in the development and progression of DN. Measuring level of uMCP-1 is very important in the diagnosis and intervention of early DN.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2008年第2期242-244,共3页
Journal of China Medical University
基金
辽宁省教育厅高等学校科研基金资助项目(202013140)
辽宁省自然科学基金资助项目(20032068)
关键词
糖尿病
糖尿病肾病
单核细胞趋化蛋白-1
diabetes mellitus
diabetic nephropathy
monocyte chemoattractant protein-1
