摘要
胰腺癌是外科恶性程度最高的肿瘤之一，随着分子生物学的发展，对胰腺癌的发病机制也有了很大的了解。胰腺癌细胞中存在着多种信号通路传导的异常，包括：Notch信号通路，k-ras信号通路，hedghog信号通路，NF-κB信号通路等，其中由于NF-κB信号的改变在胰腺癌细胞中普遍存在，故考虑NF-κB在胰腺癌各信号通路相互作用中有着重要地位，本文针对NF-κB在胰腺癌细胞中参与的相关信号通路进行综述。
Pancreatic cancer is one of the most malignant diseases. With the development of biology, its pathogenesis has become more and more clear. There are a lot of signal pathway aberrant in pancreatic cancer cell including Notch signal pathway, k-ras signal pathway, hedghog signal pathway, NF-κB signal pathway and so on. Because of the widespread of NF-κB signal pathway aberration in pancreatic cancer cell, we think that NF-κB play a key role in the various kinds of aberrant signal pathways. So the NF-κB relative signal pathways in pancreatic cancer are reviewed in this article.
出处
《国际外科学杂志》
2008年第4期273-276,共4页
International Journal of Surgery
