摘要
大量动物实验表明环境雌激素(EEs)具有生殖和(或)发育毒性,其致雄性生殖系统发育畸形的机制复杂,尤其作用途径目前仍很不明了。本文从EEs干扰睾丸发育、影响睾丸激素产生、代谢并进而致雄性生殖系统发育畸形的可能途径介绍近年来国内外取得的进展。
It has been shown that numerous natural and synthetic chemicals with estrogenic activities have reproductive or developmental toxicity in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity that could result in male reproductive system maldevelopment, however, are very complicated, especially in the exact pathways. This article introduced the current progress on the potential pathways of environmental estrogens （exoestrogens, xenoestrogens） interfered with the testicular development, testicle hormone production and their metabolism.
出处
《生殖医学杂志》
CAS
2008年第2期151-155,共5页
Journal of Reproductive Medicine
基金
国家自然科学基金资助(30571935)
