摘要
目的探讨快速测定脑钠肽(BNP)在早期诊断非ST段抬高急性心肌梗死(NSTEMI)中的价值。方法选择非ST段抬高的急性冠状动脉综合征(NSTEACS)患者101例,NSTEMI患者48例,不稳定性心绞痛(UAP)患者53例,健康对照组50例,测定每位患者的血浆BNP、肌钙蛋白(cTnT)、肌酸磷酸激酶-同工酶(CK-MB)、C反应蛋白(CRP)水平。结果非ST段抬高心肌梗死组患者血浆脑钠肽浓度(256±74)ng/L显著高于不稳定性心绞痛组,(85±38)ng/L(P<0.01),且2组患者血浆脑钠肽浓度均高于健康对照(5.56±1.4)ng/L(P<0.01),与cTnT、CK-MB、CRP呈正相关(P<0.05)。脑钠肽升高程度与心肌缺血程度呈正相关。结论NSTEMI患者血浆BNP浓度显著高于不稳定性心绞痛患者,可床旁快速确诊NSTEMI。
Objective To investigate the rapid determination of brain natriuretic peptide （BNP） in the early diagnosis of non-ST-segment elevation acute myocardial infarction （NSTEMI） value. Methods non-ST-segment elevation acute coronary syndrome （NSTEACS） with 101 cases, 48 patients with NSTEMI, unstable angina pectoris （UAP） in 53 eases, the healthy control group, 50 patients, each of the patients with plasma BNP, cardiac troponin （cTnI）,creacine phosphokinase-isoenzyme MB（CK-MB）,C-reactive protein （CRP） levels. Results non-ST-segment elevation myocardial infarction patients plasma brain natriuretic peptide concentration was significantly higher than unstable angina group （255.6±74.53） ng/lvs（85.2±38.35） ng/L （P〈0.01,and 2 Group of plasma brain natriuretic peptide concentrations were higher than those＇in healthy control group （255.6±74.53） ng/L vs （5.56±1.35） ng/L （P〈0.01） （85.2±38.35） ng/L vs （5.56±1.35） ng/L （P〈0.01）, and cTnI, CK-MB, CRP was positively correlated （P〈=0.05. elevated levels of brain natriuretic peptide and the extent of myocardial ischemia were positively correlated, conclusion non-ST-segment elevation myocardial infarction patients with brain natriuretic peptide concentration was significantly higher than that in patients with unstable angina patients can be quickly diagnosed bedside non-ST-segment elevation myocardial infarction.
出处
《河北医药》
CAS
2008年第3期297-298,共2页
Hebei Medical Journal
关键词
非ST段抬高
急性心肌梗死
脑钠肽
免疫荧光
non-ST-segment elevation
acute myocardial infarction
brain natriuretic peptide
immunofluorescence
