摘要
多发性骨髓瘤是一种浆细胞系恶性肿瘤,依靠传统的化疗方案不能够治愈。近年来,基于对骨髓瘤生物学、遗传学以及肿瘤发生学的深入研究,开发研制出一些新药,并提出了靶向治疗的新方法,如利用蛋白酶体抑制剂、免疫调节剂等,能够极大的改善病人的预后;另外,新的联合化疗方案的出现,也明显提高了缓解率。这些新的治疗策略为临床工作带来了巨大帮助,本文对治疗多发性骨髓瘤的新看法的最近进展进行了评述。
Multiple myeloma is a neoplasm of mature and immature plasma cells, it remains an incurable disease using conventional chemotherapy and increasing aggressive approaches. In recent years, due to the better understanding of myeloma biology, genetics and tumor formation, there are lots of new active drugs or combinational chemotherapy regimens having been developed, such as proteasome inhibitors, immunomodulatory agents etc, they are more effective than conventional chemotherapy. This article summarizes the recent advances with the new options for the treatment of multiple myeloma.
出处
《中国实验血液学杂志》
CAS
CSCD
2008年第2期231-239,共9页
Journal of Experimental Hematology
