摘要
目的:观察参附注射液对老年患者手术后早期康复的影响,并探讨其可能的机制。方法:100例随机分为对照组和参附注射液(参附组),每组50例。参附组于手术前3天起至术后3天,每天用参附注射液100ml静脉滴注;对照组行常规治疗。术后每天观察并记录肠蠕动恢复时间、肛门排气时间、切口愈合情况,并作C-反应蛋白、皮质醇浓度、部分细胞因子及SOD、MDA的检测。结果:参附组与对照组比较,术后疲劳指数、C-反应蛋白、皮质醇浓度、TNF-α、MDA明显下降(P<0.01或P<0.05),IL-2、SOD水平显著提高(P<0.01)。结论:参附注射液能降低手术后应激反应,减少炎症因子的表达,减轻组织损伤,在一定程度上促进老年患者手术后的早期康复。
Objective：To explore the effect of shenfu injection on early rehablilitation of the senile patients after surgery and discuss the possible mechanisms. Methods： 100 cases were randomly divided into the contrast group（ C group with 50 cases） and the shenfu group（ SF group with 50 cases）. The SF group was treated by mainline with 100ml shenfu injection 3 days before and after surgery, and the day taking surgery. The C group was treated by normally. The clinical symptoms were observed each day and the time of intestines creepage, anus exhaust, and incision concrescence was recorded. The level of C reactive protein, hydrocortisone concentration, some cell genes, SOD and MDA were also measured. Results： The fatigue score after operation, the level of C reactive protein, hydrocortisone concentration, TNF-α and MDA in the SF group were obviously decreased than those in the C group（ P 〈 0.0 1 or P 〈 0.05 ）. The level of IL-2 and SOD in the SF group was significantly improved than that in the C group（P 〈 0.0 1 ）. Conclusion： Shenfu injection can decrease the response to a stimulus, the express of inflammatory factor, the systematical trauma after operation. It can improve the early rehabilitation of the senile patients after general surgery.
出处
《浙江中西医结合杂志》
2008年第4期201-202,205,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金
浙江省温州市医药卫生科学研究项目(No.2007Z10)
