摘要
目的观察降纤酶联合紫外线葡萄糖照射法对前部缺血性视神经病变和视网膜中央静脉阻塞患者高血黏度的改善作用。方法本院眼底病组住院的血液流变学学检测异常的前部缺血性视神经病变(AION)患者70例和视网膜中央静脉阻塞(CR—VO)患者62例,经眼底、视野、眼底血管荧光素造影检查并依相应诊断标准确诊。将男女患者分别分为对照组和治疗组,对照组单纯静脉输入降纤酶;治疗组行降纤酶载氧法,即采用氧透射载体治疗仪,将降纤酶通过输液器在氧载体透照窗经过石英管进行紫外线照射后静脉输入体内。两组每日治疗1次,10d后复查血液流学变化并对其结果进行统计学分析。结果两种方法对AION和CRVO患者异常血液流变学的改善作用有所不同,除均能降低男、女患者的高切黏度、低切黏度、纤维蛋白原外(P<0.05);降纤酶载氧组疗效更优,并对男性患者的胆固醇有降低作用(P<0.05),对血细胞比容和甘油三脂有明显降低作用(P<0.05或P<0.01)。结论降纤酶能改善高血黏度,而降纤酶联合紫外线葡萄糖照射法对高血黏度改善的效果更显著,且具方便、安全特点,是一种改善高血黏度的有效方法。
Objective To investigate the effects of defibrase drugs with light quantum on the changes in hemorrheologic behavior and the level of blood lipid for anterior ischemic optic neuropathy（AION） and central retinal vein occlusion （CRVO）. Methods A total of 132 patients with AION and CRVO, selected from the center of the Fourth Hospital of Xihn, were divided into two groups by hemorrheologic behavior, each group involved 66 patients, randomly divided into treatment and control groups and males and females. Several items of hemorheology in 132 cases （66 males and 66 females） were treated with different methods with same drug to ameliorate the abnormal hemorrheologie blood behavior. Sixty six patients were given difibrase 10 U in 5% glucose solution iv drip,qd. Sixty six patients were given same doses defibrase in 5% glucose solution iv drip,qd, and at the same time light quantum was used. Hematoerit（HCT） ,fibrinogen, cholesterol, triglyeeride （TG） and other items were examined before and after the therapy. After 10 day treatment, the changes in hemorheology and blood lipid were observed and compared respectively in each pair. The results in different groups is analyzed retrospectively. Results Indices of hemorheology in different methods with same drug were markedly reduced （ P 〈 0. 05 ）. The effect of treatment groups with light quantum was greater than that of control group. The indices of hemorheology such as high-shearing viscosity, low- shearing viscosity, red cell hematoerit, fibrinogen, and total cholesterol of blood lipid, were with significant difference compared with those of control group before and after treatment（P 〈0. 01 or 〈 0. 05）. Conclusions The drug treatment with light quantum on high blood viscosity in comparison with the control group is different for abnormally hemorrheologie behavior recovery. Choosing light as the suitable method with same drug is better for the therapeutic efficacy on treating AION and CRVO.
出处
《中国激光医学杂志》
CAS
CSCD
2007年第6期349-353,共5页
Chinese Journal of Laser Medicine & Surgery
基金
陕西省卫生厅重点科技计划项目(2004AC1)
关键词
高血黏度
前部缺血性视神经病变
视网膜中央静脉阻塞
载氧
降纤酶
High blood viscosity
Anterior ischemic optic neuropathy
Central retinal vein occlusion
Light quantum
Proteasel
