摘要
目的:检测盐酸环丙沙星胃漂浮缓释片与普通片在家犬体内的生物利用度。方法:采用高效液相色谱法测定家犬体内的血药浓度。用3P97药动学程序拟合,计算药动学参数并评价生物等效性。结果:盐酸环丙沙星普通片和胃漂浮缓释片的Cmax分别为(3.7±0.7)mg·L-1和(2.5±0.8)mg·L-1,tmax分别为(1.8±0.8)h和(3.7±0.5)h,AUC0→24分别为(20.5±3.7)mg·h·L-1和(21.4±4.7)mg·h·L-1,MRT分别为(5.7±0.5)h和(7.5±0.7)h,相对生物利用度Fr=104.2%。结论:盐酸环丙沙星胃漂浮缓释片有很好的缓释效果,与参比制剂生物等效。
OBJECTIVE To study the pharmacokinetics and bioavailability of ciprofloxacin hydrochloride intra-gastric floating sustained release tablets and its conventional tablets in six male dogs. METHODS The concentrations of ciprofloxacin hydrochloride in plasma were determined by HPLC method. The main pharmacokinetic parameters of relative bioavailability of the sustained release capsules were obtained using 3P87 program. RESULTS The Cmax of the two preparations were（3. 7±0. 7） mg·L^-1 and（2. 5±0. 8）mg·L^-1 respectively, t were （ 1.8 ± 0. 8）h and（3. 7 ± 0. 5）h and MRT were（5. 7±0. 5）h, （7. 5 ±0. 7） h respectively. AUG0→24 were（2（1. 5 ＋ 3. 7）mg·h·L^-1 and （21.4±4. 7）mg·h·L^-1 , The relative bioavailability of the sustained- release tablets was 104. 20%. CONCLUSION By the statistical analysis, the ciprofloxacin hydrochloride intra - gastric floating sustained release tablets have good sustained release characteristics and were bioequivalent to the reference formulation.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第6期423-425,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸环丙沙星
胃漂浮缓释片
药动学
生物利用度
ciprofloxacin hydrochloride
intra-gastric floating sustained release tablets
pharmacokinetics
bioavailability
