摘要
本文对中国2000年～2006年发酵乳制品行业常用的137株益生菌菌种进行了毒力试验安全性评价，同时检测了31株益生菌对20种抗生素的耐药性，初步评估中国目前所使用的益生菌菌种安全性。结果表明：除一株鼠李糖乳杆菌外，其余益生菌菌种均为安全的。31株益生菌均对下列抗生素敏感：氨苄西林、青霉素、亚胺培南、庆大霉素、阿莫西林、阿莫西林／棒酸、加替沙星、红霉、素克林霉素、四环素、利福平和头孢噻肟；而对萘啶酮酸、万古霉素和磷霉素的耐药率较高。
In this study, we analysised the safety of 137 strains of starters culture bacteria in fermented milk between 2000 and 2006 in China. The study was designed to evaluate the acute oral toxicity of 137 strains to mice, and 31 of 137 strains for Minimum inhibitory concentrations（ MIC ） of 20 kinds of antibiotics by broth micro-dilution method. The result indicated that except a strain of Lactobacillus rhamnosus, other probiotics were non-pathogenic and safe for human consumption. 31 strains of probiotics were sensitive to Ampicillin, Penicillin, Imipenem, Gentamicine, Amoxicillin, Amoxicillin/clavulanic acid, Gatifloxacin, Erythromycin, Clindamycin, and Were resistant to Nalidixic acid, Vancomycine, Fosfomycin
出处
《卫生研究》
CAS
CSCD
北大核心
2008年第2期193-195,共3页
Journal of Hygiene Research
关键词
益生菌
耐药性
安全性评估
乳制品
probiotics, antibiotic susceptibility testing, safety assessment
