摘要
目的:从脑组织p53的表达变化的角度来探讨前列地尔对大鼠局灶性脑缺血的防治机制及其量效关系。方法:采用大脑中动脉闭塞方法建立局灶性脑缺血动物模型,观察低、中、高剂量前列地尔对局灶性脑缺血大鼠大脑皮质p53表达的影响。结果:前列地尔各组大鼠脑组织p53表达平均灰度分别为115.75±11.38、140.13±11.38、156.21±10.05,均高于缺血对照组97.91±10.01。结论:前列地尔防治大鼠局灶性脑缺血损伤的机制可能与抑制脑组织p53表达有关,且以高剂量效果较好。
Objective：To study the effects of Prostaglandin-E1 on the expressions of p53 in brain tissue after focal cerebral ischemia in rats and the dosage-effect relationship. Methods：We adopted the middle cerebral artery occlusion （MCAO） in rats as the focal cerebral ischemia model and observed the changes of the expressions of p53 in cerebra cortex. Results： The average gray of p53 in Prostaglandin-E1 groups were 115. 75±11.38,140. 13±11. 38,156. 21±10. 05, respectively, higher than focal cerebral ischemia group 97. 91±10. 01 （P〈0. 05）. Conclusion.Prostaglandin-E1 can protect the brain cells from damage after focal cerebral ischemia injury by adjusting the expressions of p53, and the high-dose Prostaglandin-E1 is more effective.
出处
《数理医药学杂志》
2008年第2期174-175,共2页
Journal of Mathematical Medicine
