摘要
吡喹酮抗血吸虫成虫的药理作用与Ca2+稳态的破坏有直接关系。电压门控Ca2+通道(VGCC)是调节细胞内Ca2+水平的重要参与者。研究显示Ca2+通道的亚基可能是吡喹酮的作用靶点。本文就血吸虫以及扁形动物门的其他寄生虫的VGCC的结构和功能,以及Ca2+通道的亚基在吡喹酮抗血吸虫作用机制的研究进展进行综述,以期为抗血吸虫新药研究提供参考。
Pharmacological actions of praziquantel against schistosome adult worms are thought to be directly linked to the disruption of Ca^2＋ homeostasis. The voltage-gated Ca^2＋ channel is an important factor in regulating the intracellular Ca^2＋ level. Studies have revealed that Ca^2＋ channel subunits may be the target for the action of praziquantel. This review summarizes the progress on the structure and function of the Ca^2＋ channel of Schistosoma spp and other Platyhelminths as well as the role of Ca^2＋ channel in action of praziquantel.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2008年第1期58-62,共5页
Chinese Journal of Parasitology and Parasitic Diseases
