摘要
[目的]探讨脑源性神经营养因子(BDNF)与涎腺腺样囊性癌(SACC)的关系。[方法]采用免疫组织化学方法检测45例SACC切片中BDNF的表达,并统计分析BDNF与SACC组织学分型、临床分期、神经侵犯和远处转移之间的关系。[结果]BDNF在SACC中的阳性表达率为84.4%(38/45),BDNF表达强度与SACC的组织学分型和神经侵犯无明显关系(P>0.05),而与临床分期、远处转移关系密切(P<0.05)。[结论]SACC中存在BDNF异常表达,而且BDNF可能促进了SACC的发生发展。
[Purpose] To investigate the relationship between the expression of brain-derived neurotrophic factor（BDNF） and salivary adenoid cystic carcinoma （SACC）. [Methods] The expression of BDNF in 45 cases with SACC was detected by immunohistochemistrial method. The relationship between BDNF expression and histological type,clinical staging,perineural invasion and distant metastasis was analyzed. [Results] The positive expression of BDNF in SACC was 84.4%（38/45）. The expression level of BDNF wasn’t significantly correlated with histological type and perineural invasion （P〉0.05）,but correlated with clinical staging and distant metastasis （P〈0.05）. [Conclusions] BDNF is aberrantly expressed in SACC,and it might promote carcinogenesis and progression of SACC.
出处
《中国肿瘤》
CAS
2008年第3期221-223,共3页
China Cancer
基金
安徽省自然科学基金(KJ2007B361zc)
关键词
涎腺肿瘤
癌
腺样囊性
脑源性神经营养因子
免疫组织化学
salivary gland neoplasms
carcinoma,adenoid cystic
brain-derived neurotrophic factor
immunohistochemistry
