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多发性骨髓瘤的细胞遗传学研究进展 被引量:3

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摘要 多发性骨髓瘤(Multiple Myeloma, MM)是累及骨髓和骨质的浆细胞恶性疾病.1959年即有人对其进行了细胞遗传学研究,但直到1972年G显带技术出现后才发现了MM的特殊标记染色体14q^+.随后大量的研究表明染色体异常在MM的病理发展过程中具有相当重要的意义.
作者 佟刚 魏素芳
出处 《国外医学(输血及血液学分册)》 CAS 北大核心 1990年第3期137-139,共3页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
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  • 1张艳,江滨,黄晓军,师岩,何琦,党辉,邱镜滢,陆道培.多发性骨髓瘤的细胞遗传学研究[J].中国实验血液学杂志,2007,15(1):76-78. 被引量:20
  • 2Lai JL,Zandecki M,Mary JY,et al.Improved cytogeneties in multiple myeloma:a study of 151 patients including 117 patients at diagnosis.Blood,1995,85,2490-2497. 被引量:1
  • 3Nilsson T,Lenhoff S,Rylander L,et al.High frequencies of chromosomal aberrations in multiple myeloma and monoclonal gammaopathy of underter mined significance in direct chromosome preparation.Br J Haematol.2004,126:487-494. 被引量:1
  • 4Debes-marum CS,Dewald GW,Bryant S,et al.Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma.Leukemia,2003,17:427-436. 被引量:1
  • 5Magrangeas F,Lode L,Wuilleme S,et al.Genetic heterogenety in multiple myeloma.Leukemia,2005,19:191-194. 被引量:1
  • 6Zhang F,Sawyer J,Tricot G.The role of cytogeneties in myeloma.Leukemia,2006,20:1484-1486. 被引量:1
  • 7Zojer N,Konigsberg R,Ackermann J,et al.Deletion of 13ql4 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization.Blood,2000,95:1925-1930. 被引量:1
  • 8Philip RG,Jesus SM,Brian GMD,et al.International staging system for multiple myeloma.J Clin Oncol,2005,23:3412-3420. 被引量:1
  • 9Gutierrez NC,Castellanos MV,Martin M L,et al.Prognostic and biological in placations of genetic abnormalities in multiple myeloma undergoing autologous stem cell transplantation:t(4; 14) is the most relevant adverse prognostic factor,where as RB deletion as a unique abnormality is not associated with adverse prognosis.Leukemia,2007,21:143-150. 被引量:1
  • 10Debes-Marum CS, Dewald GW, Bryant S, et al. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia, 2003 ; 17:427 - 436 被引量:1

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