摘要
目的探讨奥氮平与氟西汀联合治疗抑郁症的效果。方法将符合CCMD-3抑郁症诊断标准的病人80例,随机分成两组,分别用奥氮平联合氟西汀（联合组）和单用氟西汀（单用组）治疗6周,采用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）分别于治疗第1、2、4、6周末评分,用副反应量表（TESS）评定不良反应。结果第6周末联合组HAMD评分低于单用组,第2周末、第6周末联合组的HAMD平均减分率高于单用组,差异均有显著性（t=3.92-7.48,P〈0.01）。两组间的不良反应差异无显著性。结论奥氮平联合氟西汀治疗抑郁症的效果优于单用氟西汀。
Objective To assess the efficacy of combined olanzapine with fluoxetine for depression. Methods Eighty patients who met CCMD-3 standard were randomized to two groups： combination group, ollanzapine plus fluoxetine were given; fluoxetine group, given only fluoxetine. The medication lasted for six weeks in both groups. An evaluation was made at the end of 1, 2, 4 and 6 weeks with Hamiltion Depression Scale （HAMD） and Hamiltion Anxiety Scale （HAMA）. The side effects were assessed by Treatment Emergent Symptom Scale （TESS）. Results The HAMD scores in combination group was significantly lower than fluoxetine group at the end of sixth week, The score-reducing rate of HAMD from the second to sixth week was greater in the combination than that treated with fluoxetine alone （t= 3.92-7.48, P〈0.01）. The side effects were similar between the two groups. Conclusion Olazapine in combination with fluoxetine is superior to giving fluoxetine alone in treating depression.
出处
《齐鲁医学杂志》
2008年第1期62-63,共2页
Medical Journal of Qilu
关键词
奥氮平
氟西汀
抑郁症
治疗结果
Olanzapine
Fluoxetine
Depression
Treatment outcome
