摘要
目的探讨血清胰岛素样生长因子结合蛋白2（insulin—like growth factor binding protein 2，IGFBP-2）水平与肝细胞癌的关系及其在肝癌的诊断、治疗中潜在使用价值。方法采用酶联免疫吸附试验ELISA法测定的肝细胞癌组（54例）血清IGFBP-2／3、AFP、IGF—1、IGF-2、GH水平与肝硬化组（20例）和健康对照组（32例）结果进行比较。结果肝细胞癌组血清IGFBP-2水平明显高于肝硬化组和健康对照组（t=4．63，P〈0．05；t=3．73，P〈0．01），肝硬化组与健康对照组比较差异无统计学意义。肝癌切除术后4周IGFBP-2水平明显下降，与术前相比差异有统计学意义（t=3．52，P〈0．05）。肝细胞癌组GH、IGF-1／2、IGFBP-3水平与肝硬化组对比差异无统计学意义。相关性分析显示肝细胞癌组IGFBP-2与AFP水平呈正相关（r=0．51，P〈0．05），与GH、IGF-1／2、IGFBP-3无相关性。结论肝细胞癌患者血清IGFBP-2水平的异常增高可能与肝癌细胞合成释放增加有关。与AFP结合使用血清IGFBP-2检测可成为肝癌筛查、动态观察的有效手段。
Objective To evaluate insulin-like growth factor binding protein-2 （ IGFBP-2 ） level in hepatocellular carcinoma （HCC） and its role in the diagnostic work-up of patients with HCC. Methods The basal serum level of IGFBP-2/3,AFP,IGF-1 ,IGF-2,GH in 54 HCC patients was compared with that in patients with hepatic cirrhosis and healthy control. Results The level of IGFBP-2 in HCC patients was higher than that of hepatic cirrhosis group and control group （ t =4. 63, P 〈0.05 ;t = 3.73, P 〈 0. 01 ）. After HCC resection, the level of IGFBP-2 decreased in 4 weeks （ t = 3.52, P 〈0.05 ）. There was no differences of the serum GH, IGF-1/2, and IGFBP-3 levels between HCC and control group. In HCC group, the serum level of IGFBP-2 and AFP correlated positively （r = 0.51, P 〈 0.05 ）. Conclusion Apart from AFP, IGFBP-2 appears to be a suitable marker of HCC, which can be applied in the diagnosis of HCC.
出处
《中华普通外科杂志》
CSCD
北大核心
2008年第1期51-53,共3页
Chinese Journal of General Surgery
关键词
癌
肝细胞
胰岛素样生长因子结合蛋白2
甲胎蛋白类
Carcinoma, hepatocellular
Insulin-like growth factor binding protein 2
Alpha-fetoproteins
