摘要
目的:探讨胰岛素样生长因子结合蛋白2(IGFBP-2)在结直肠癌中的表达情况及其与结直肠癌临床病理特征的关系。方法:采用免疫组化Maxvision法检测80例结直肠癌、50例癌旁正常黏膜和50例结直肠腺瘤中IGFBP-2的表达情况。结果:结直肠癌组织IGFBP-2蛋白的表达水平明显高于结直肠腺瘤和癌旁正常黏膜组织(P<0.01,P<0.05)。结直肠癌IGFBP-2蛋白表达与年龄、性别无关(P>0.05),与分化程度、浸润深度、淋巴结转移和Duke’s分期有关(P<0.05)。结论:IGFBP-2蛋白高表达在结直肠癌的发生发展过程中起到重要作用,可作为判断结直肠癌发生发展的预测因素。
Objective：To investigate the expression of insulin like growth factor binding protein 2（IGFBP-2） in colorectal carcinoma and the relationships between IGFBP-2 expression and clinicopathologic features of colorectal carcinoma.Methods：Maxvision immunohistochemical stain was used to detect the IGFBP-2 expression in 80 cases colorectal carcinoma, 50 cases colorectal adenomas and 50 cases adjacent normal mucosa. Results： IGFBP-2 expression in colorectal carcinoma was obviously higher than that in colorectal adenomas and adjacent normal mucosa（P〈0.01, P〈0.05）. In colorectal carcinoma, the IGFBP-2 expression was irrelevant to age and sex（P〉0.05）; but relevant to degree of differentiation, infi ltration depth, lymph node metastasis and Duke＇s stage（P〈0.05）. Conclusions： High expression of IGFBP-2 protein plays important role in development of colorectal carcinoma, which can be acted as predictive factors for judging development of colorectal carcinoma.
出处
《承德医学院学报》
2015年第2期97-99,共3页
Journal of Chengde Medical University
