摘要
腺苷对缺血再灌注心肌具有保护作用,其主要机制为:改善心肌微循环、抑制中性粒细胞功能、抑制氧自由基产生、改善心肌能量代谢、维持钙稳态、促进血管修复及改善心室重构、介导预处理与后处理效应,这些作用主要是由分布于心肌的各型腺苷受体介导的,目前已被用于心肌梗死、心律失常的防治及心脏停搏法、经皮冠状动脉内成型术、心脏移植术中。
Adenosine has been found to be cardioprotective during cardiac ischemia/repeffusion. The potential mechanisms was reported to be associated with improvement of cardiao microvascular blood flow, inhibition of neutrophils function, inhibition of production of oxygen-derived free radicals, improvement of cardiac energy metabolism,maintenance of calcium homeostasis, promotion of vascular repairment and inhibition of ventricttlar remodeling and mediation of pre-and post-condition. Adenosine has been used in acute myocardial infarction,an＇hythmia, cardioplegia, percutaneous transcoronary angioplasty and heart transplantation. These effects are mediated by adenosine receptor subtypes distributed in the myocardium.
出处
《医学综述》
2008年第5期769-772,共4页
Medical Recapitulate
关键词
腺苷
心肌保护
腺苷受体
Adenosine
Cardio-protecfion
Adenosine-receptor
