摘要
设计合成了2-[(2'-芴基)-乙烯基]-8-羟基喹啉(6)、2-[(2'-菲基)-乙烯基]-8-羟基喹啉(7)及其金属锌配合物8和9;用UV-Vis,FT-IR,ESI-MS,1HNMR和元素分析确认了化合物6和7的结构;并用四甲基偶氮唑盐微量酶反应比色法(MTT法)研究了其调控骨髓间质干细胞增殖的作用,结果表明,化合物6和7对干细胞有明显的增殖作用.用FT-IR,FAB-MS和元素分析表征了金属锌配合物结构,光致发光光谱测试结果表明,化合物8的发光峰值为602nm,发黄光;化合物9的发光峰值为628nm,发橙红色光.
The 2-（2-（9H-fluoren-2-yl） vinyl）-8-hydroxyquinoline （6） and 2-（2-（phenanthren-9-yl） vinyl）-8-hydroxyquinoline （7） and their zinc complexes 8 and 9 have been synthesized. Compounds 6 and 7 were confirmed by UV-Vis, FT-IR, ESI-MS, ^1H NMR and elemental analysis. Regulation of the mesenchymal stem cells by compounds 6 and 7 have been evaluated by MTT assay, and the results show that these compounds have the ability to induce the proliferation of the mesenchymal stem cells. The zinc complexes were determined by FT-IR, FAB-MS and elemental analysis. Photoluminescence spectra show that the emission peaks of compounds 8 and 9 are at 602 and 628 nm, with yellow and red light emitted, respectively.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2008年第4期465-470,共6页
Acta Chimica Sinica
基金
国家自然科学基金(Nos.20471020
20671036)
广东省科技项目(No.2006A10801002)资助项目
关键词
8-羟基喹啉
骨髓间质干细胞
荧光光谱
8-hydroxyquinoline
mesenchymal stem cell
fluorescence spectra
