摘要
腺癌是非小细胞肺癌(NSCLC)中常见的类型之一,2004版WHO肺癌病理与遗传学分类根据形态学特征将肺腺癌分为10个组织学亚型。虽然从组织学上看,低分化腺癌患者更常见淋巴结转移以及术后复发;乳头状结构、高组织学级别、核分裂象的增多以及肿瘤的广泛坏死等都是预后不良的指标。然而各亚型和预后之间没有明确的对应关系,组织学亚型通常缺乏明确的预后价值。
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2008年第3期190-192,共3页
Chinese Journal of Pathology
参考文献23
-
1Travis WD, Brambilla E, MuUer-Hermelink HK, et al. World Health Organization classification of tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004:35-44. 被引量:1
-
2Naruke T,Goya T, Tsuchiya R, et al. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg, 1988, 96(3 ) :440-447. 被引量:1
-
3Perez-Enciso M, Tenenhaus M. Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach. Hum Genet, 2003, 112(5-6) :581-592. 被引量:1
-
4Kallioniemi AK, Kallioniemi OP, Sudar D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science, 1992, 258(5083) :818-821. 被引量:1
-
5Pinkel D, Segraves R, Sudar D, et al. High resolution analysis of DNA copy number variation using comparative genomichybridization to microarrays. Nat Genet, 1998, 20 (2) : 207-211. 被引量:1
-
6Meyerson M, Carbone D. Genomic and proteomic profiling of lung cancers : lung cancer classification in the age of targeted therapy. J Clin Oncol, 2005, 23(14) :3219-3226. 被引量:1
-
7Garber ME, Troyanskaya OG, Schluens K, et al. Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A, 2001,98(24) :13784-13789. 被引量:1
-
8Bhattacharjee A, Treyanskaya OG, Schluens K, et al. Classification of human lung carcinomas by mRNA expression prefiling reveals distinct adenocarcinoma subclasses. Prec Nail Acad Sci U S A, 2001, 98(24) :13790-13795. 被引量:1
-
9Takeuchi T, Tomida S, Yatabe Y, et al. Expression profiledefined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors. J Clin Oncol, 2006, 24 ( 11 ) : 1679- 1688. 被引量:1
-
10Hayes DN, Monti S, Parmigiani G, et al. Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. J Clin Oncol, 2006, 24 (31) :5079-5090. 被引量:1
二级参考文献20
-
1Jaffe ES,Harris NL,Stein H,et al.Eds.World Health Organization classification of tumors.Pathlogy and genetics of tumours of haematopoietic and lymphoid Tissues.Lyon:IARC Press,2001.171-187. 被引量:1
-
2The International non-Hodgkin's lymphoma Prognostic Factors Project.A predictive model for aggressive non-Hodgkin's lymphoma.N Engl J Med,1993,329:987-994. 被引量:1
-
3Alizadeh AA,Eisen MB,Davis ER,et al.Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.Nature,2000,403:503-511. 被引量:1
-
4Rosenwald A,Wright G,Chan WC,et al.The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.N Engl J Med,2002,346:1937-1947. 被引量:1
-
5Lossos IS,Alizadeh AA,Eisen MB,et al.Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas.Proc Natl Acad Sci U S A,2000,97:10209-10213. 被引量:1
-
6Huang JZ,Sanger WG,Greiner TC,et al.The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile.Blood,2002,99:2285-2290. 被引量:1
-
7Iqbal J,Sanger WG,Horsman DE,et al.Bcl2 translocation defines a unique tumor subset with in the germinal center B-cell-like diffuse large B-cell lymphoma.Am J Pathol,2004,165:159-166. 被引量:1
-
8Davis RE,Brown KD,Siebenlist U,et al.Constitutive nuclear factor kB activity is required for survival of activated B cell-like diffuse large B-cell lymphoma cells.J Exp Med,2001,194:1861-1874. 被引量:1
-
9Lu XQ,Nechushtan H,Ding FY,et al.Distinct IL-4-induced gene expression,proliferation,and intracellular signaling in germinal center B-cell like and activated B-cell-like diffuse large-cell lymphomas.Blood,2005,105:2924-2932. 被引量:1
-
10Savage KJ,Monti S,Kutok JL,et al.The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Blood,2003,102:3871-3879. 被引量:1
共引文献11
-
1陈杰.再接再厉,努力提高我国的病理诊断和研究水平[J].中华病理学杂志,2006,35(11):642-643. 被引量:4
-
2王珊,王晋芬,王国平.MIB1与TopoⅡα在弥漫大B细胞淋巴瘤的表达及其与预后的关系[J].白血病.淋巴瘤,2008,17(5):367-368. 被引量:1
-
3张子臻,倪醒之,殷晓璐,沈丹平,沈艳莹.胃肠道弥漫性大B细胞淋巴瘤免疫表型与预后的研究[J].中华普通外科杂志,2008,23(12):946-949. 被引量:4
-
4张子臻,倪醒之.淋巴结内及胃肠道弥漫性大B细胞淋巴瘤的分型及其临床意义[J].中国实用外科杂志,2009,29(3):274-277. 被引量:10
-
5王富强,顾霞.CD10、BCL-6、MUM1在弥漫大B细胞淋巴瘤中表达及其临床病理意义[J].新疆医科大学学报,2009,32(2):131-133. 被引量:1
-
6王国平,郗彦凤,李义,王晋芬,白纬.bcl-2与bcl-6在弥漫性大B细胞淋巴瘤中表达的研究[J].白血病.淋巴瘤,2009,18(10):588-591. 被引量:9
-
7郗彦凤,王国平,李义,王晋芬,孙瑞芳.Bcl-2与弥漫大B细胞淋巴瘤免疫学亚型及预后的关系[J].中华血液学杂志,2010,31(1):34-37. 被引量:8
-
8张子臻,倪醒之,沈艳滢,殷晓璐.胃肠道弥漫性大B细胞淋巴瘤中之t(14;18)染色体易位及Bcl-2基因扩增的研究[J].外科理论与实践,2010,15(2):143-147. 被引量:3
-
9刘少芝,左云海.CARD11与NF-_κB及Bcl-2在弥漫性大B细胞淋巴瘤中的表达及意义[J].临床合理用药杂志,2012,5(21):12-13. 被引量:1
-
10周智俊,谢建兰,韦萍,周小鸽.原发性乳腺淋巴瘤类型构成与预后分析[J].中华病理学杂志,2017,46(9):618-622. 被引量:13
同被引文献58
-
1王之敏,陶承.恶性脑胶质瘤分子靶向治疗研究进展[J].中国肿瘤,2006,15(3):158-162. 被引量:3
-
2方家椿.分子靶点和分子靶向抗肿瘤药研究进展[J].北京大学学报(医学版),2006,38(6):575-578. 被引量:12
-
3汪世容,关柏林.转化医学:B2B医疗新模式.文汇报,2008-11-08(7). 被引量:1
-
4Vanden Bempt I, Van Loo P, Drijkoningen M, et al. Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing. J Clin Oncol, 2008, 26(30) :4869-4874. 被引量:1
-
5Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2008 : 233-237. 被引量:1
-
6Feder JN, Gnirke A, Thomas W, et al. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet, 1996, 13(4):399-408. 被引量:1
-
7Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer, 2006, 42 ( 8 ) : 1093-1103. 被引量:1
-
8Cobo M, Isla D, Massuti B, et al. Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: a phase Ⅲ trial in non-small-cell lung cancer. J Clin Oncol, 2007, 25(19):2747-2754. 被引量:1
-
9Olaussen KA, Dunant A, Fouret P, et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med, 2006, 355(10) :983-991. 被引量:1
-
10Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature, 2008, 455 (7216) : 1061-1068. 被引量:1
引证文献4
-
1朱雄增.分子医学时代的外科病理学[J].中华病理学杂志,2009,38(1):3-4. 被引量:5
-
2张品南,冯国飞,陈艳梅.肿瘤分子分型与靶向治疗[J].医学研究杂志,2009,38(6):9-11. 被引量:1
-
3周红桃,符生苗.分子诊断与肿瘤的个体化治疗[J].海南医学,2010,21(22):5-8. 被引量:2
-
4刘道义.分子诊断在肿瘤个体化治疗中的应用[J].中外医学研究,2015,13(8):162-164.
二级引证文献8
-
1郑杰.重视乳腺癌规范的常规病理学检查[J].中华病理学杂志,2009,38(1):5-7. 被引量:5
-
2毛峥嵘,周韧,张昕霞,Hans Konrad Mueller-Hermelink,Andreas Rosenwald.基因表达谱芯片在B细胞淋巴瘤分子分型、预后和治疗中的研究进展及应用前景[J].中华病理学杂志,2009,38(11):785-789. 被引量:1
-
3常秀青,齐文安,王世贤,贺芳,续晓龙.抓住机遇 促进发展[J].中华病理学杂志,2011,40(1):4-5. 被引量:3
-
4来茂德.中国病理学发展的现状和未来[J].中华病理学杂志,2012,41(1):1-3. 被引量:17
-
5张品南,冯国飞,陈艳梅,黄益.临床分子病理检查的发展与展望[J].医院管理论坛,2014,31(1):11-13. 被引量:3
-
6何静云,李耀华.肿瘤个体化治疗相关基因突变检测试剂实验室性能评估要求解析[J].中国医药生物技术,2015,10(5):469-471.
-
7胡艳萍.PBL主导的多元化教学在临床病理学教学中的应用[J].基础医学教育,2017,19(11):808-811. 被引量:8
-
8郏莉莉,张喆.乳腺癌分子诊断的应用进展[J].东南大学学报(医学版),2022,41(2):291-293.
-
1吴礼高,朱清,于东红,承泽农.乳腺浸润性微乳头状癌组织中MMP-9、uPAR和VEGF-C蛋白的表达和意义[J].淮海医药,2014,32(1):1-2.
-
2丁金旺,罗定存,叶柳青,邓甬川,王克义,张卧,潘钢,周美琪,秦卫民,蔡菊芳.乳腺癌患者血清中TBX3的表达及其与临床病理特征的关系[J].浙江医学,2013,35(18):1640-1643. 被引量:1
-
3蒋树娟,仲兰荪,魏英,杜心垿.CD44在乳腺癌中的表达与预后的关系[J].中国癌症杂志,1999,9(4):281-283. 被引量:1
-
4王宝娜,王翔,王靖,宣立学,王仲照,王昕,高纪东,张海增.4323例乳腺癌腋窝淋巴结转移的相关因素分析[J].中国医刊,2014,49(3):32-34. 被引量:8
-
5张丽莉,刘晓丽.微小染色体维持蛋白7在子宫内膜癌中的表达[J].中国妇幼健康研究,2010,21(6):758-760. 被引量:5
-
6向敏峰,刘德森,陈发龙,左传田,陈军,罗元.非小细胞肺癌中Survivin蛋白与p63蛋白的表达及其相关性[J].广西医科大学学报,2005,22(2):228-231.
-
7周文,袁枚.肺癌细胞DNA含量与肺癌病理形态学及预后的关系[J].中华病理学杂志,1991,20(3):184-186. 被引量:2
-
8陈至善,季桂芳.突变型P53蛋白、PCNA的表达与肺癌病理组织学的关系[J].临床肿瘤学杂志,1998,3(1):42-44. 被引量:1
-
9齐景红,郭振军,牛玉军.MSCT对中央型小细胞与非小细胞肺癌的鉴别诊断价值[J].实用放射学杂志,2015,31(3):511-513. 被引量:14
-
10沈毅,沈瑛.职业对宣威与云锡女性肺癌病理及发病年龄的影响(附100例报道)[J].临床荟萃,1999,14(1):12-12.