摘要
目的分析西藏地区2型糖尿病肾病（ON）的临床特点。方法回顾分析2001年5月至2006年10月间在我科住院的306例2型糖尿病（DM）患者的临床资料。结果306例DM患者包括151例DN和155例非DN患者，根据尿白蛋白及Ser水平，DN组患者再分为微量白蛋白尿组、临床蛋白尿组和肾功能不全组。DN组尿微量白蛋白、Scr和血、尿β2微球蛋白（MG）均较非DN组显著增高（均P〈0．01）；且尿微量白蛋白与收缩压、血β2-MG呈正相关（r-0．187，P〈0．05；r=0．297，P〈0．01），而与GFR呈负相关（r=-0．287，P〈0．01）。DN组高血压发生率高（60．27％），血压显著高于非DN组（P〈0．01），且以收缩压更显著。DN组发生尿毒症者14例（9．27％），死亡8例（5．30％），其中5例死于尿毒症；并发糖尿病视网膜病变20例（13．25％）；发生心脑血管意外者6例（3．97％）。结论西藏地区2型糖尿病肾病早期即有明显的蛋白尿、血压及血、尿β2-MG增高，后期GFR急剧下降且并发症多而严重。
Objective To analyze the clinical characteristics of patients with type 2 diabetic nephropathy （DN） in Tibet area. Method Clinical data of 306 patients with type 2 diabetes mellitus （DM） in our hospital from may 2001 to october 2006 were retrospectively analyzed. Results Above 306 patients included 151 cases of DN and 155 cases of non-DN , then the DN patients were divided into microalbuminuria group （n=30）, clinical albuminuria group （n=84） and renal insufficiency group （n=37） by the urinary albumin level. As compared to non-DN group, urinary albumin, Ser, β2 microglobulin （MG） increased significantly in DN group （P〈0.01）. Urinary albumin was positively correlated with beth systolic pressure and blood β2 -MG （r=0.187, P〈0.05; r=0.297, P〈0.01 ）, hut negatively correlated to glomerular filtration rate （GFR）（r=-0.287, P〈0.01 ）. Patients in DN group had higher incidence of hypertension （60.27%）and higher blood pressure compared with non-DN patients （P〈0.01）. In DN patients, 14 cases （9.27%） were suffered from uremia; 8 cases （5.30%） were dead among whom 5 died of uremia; 20 patients （13.25%） were complicated with diabetic retinopathy and 6 （3.97%） with cardiocerebrovascular diseases. Conclusions Significant increment of urinary albumin, blood pressure and β2-MG of blood and urine can be found in early stage of type 2 DN patients in Tibet area, meanwhile the GFR decreases obviously and complications are quite common and severe in late stage of DN.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2008年第2期115-118,共4页
Chinese Journal of Nephrology
关键词
糖尿病肾病
蛋白尿
高血压
高原
低氧
Diabetic nephropathy
Proteinuria
Hypertension
Plateau
Hypoxia
