摘要
目的探讨中晚期舌鳞癌术前明确原发灶未侵犯下颌骨,行下颌骨旁正中劈开术在中晚期舌鳞癌联合根治术中的可行性、必要性及其方法。方法对15例初治的中晚期的舌鳞癌患者,术前行平阳霉素化疗或者顺铂+5-Fu+博莱霉素4～6个周期,化疗结束后,评估原发灶。结果随访至少5年,1例失访,其中术后2年内原发灶复发2例,术后第3年复发2例。远处转移2例,局部淋巴结复发1例。结论对于未侵犯下颌骨的中晚期舌鳞癌患者,严格掌握此术式的适应证,行下颌骨旁正中劈开治疗中晚期舌鳞癌是可行的,且有助于彻底的切除原发肿瘤,减少肿瘤的复发,提高患者的生存率。
Objective To investigate the feasibility of paramedian mandibulotomy approach combined with modified neck dissection in the surgical management of advanced tongue squamous cell carcinoma. Methods 15 patients with advanced tongue squamous cell carcinoma were included. All patients received 4-6 cycles of preoperative chemotherapy with pingyangmycin or bolemycin plus cisplatin and fluorouracil. Primary mass were assessed after chemotherapy. Results The patients were followed for at least 5 years with 1 case lost during the period. Local recurrence was found in 4 cases, distance metastases occurred in 2 cases, and lymph node metastases occurred in 1 case. Conclusion Paramedian mandibulotomy approach combined with modified neck dissection is feasible for the advanced tongue squamous cell carcinoma patients. The approach can decrease relapse and improve survival.
出处
《实用癌症杂志》
2008年第2期180-181,184,共3页
The Practical Journal of Cancer
关键词
舌肿瘤
鳞状细胞癌
下颌骨劈开
Tongue tumor
Squamous cell carcinoma
Mandibulotomy
