摘要
目的:探讨新疆哈萨克族(哈族)学龄儿童β3-肾上腺素能受体(β3-AR)基因氨基酸序列第64位密码子上的色氨酸(Trp64Arg)变异型的分布特点及其与肥胖的关系。方法:选择182例哈族学龄儿童为调查对象,分为正常体重组与肥胖组,采用限制性片段基因长度多态性法进行基因多态性检测,测量身高、体重。结果:变异型等位基因(C)出现的频率为0.194,其中男童为0.210,女童为0.160。肥胖儿童变异等位基因(C)、Trp64Arg变异基因型出现的频率明显高于正常体重儿童,与性别无相关性。具有Trp64Arg变异儿童的体重指数(BMI)与无变异者无显著差异。结论:基因Trp64Arg变异在哈族学龄儿童中有一定的分布,与肥胖有一定的关系,与性别无关。
Objective： To learn the distribution feature of β3-adrenergic receptor （β3AR） Trp64Arg mutation in Karzakschool-aged children in Xinjiang and its relationship with childhood obesity. Methods： （β3AR Trp64Arg mutation was detected with the method of RFLP, their height and weight were measured. Results： The mutative Callee was 0. 194 for all the children, 0. 210 for boys and 0. 160for girls. The frequency of Callee and the genotype Trp64Arg was higher in obese children. BMI of the children with （β3-AR Trp64Arg mutation were not related to the children with Trp64Trp. Conclusion： There was distribution of （β3AR Trp64Arg mutation in Karzak school-aged children in Xinjiang. It may be related to obesity.
出处
《新疆医科大学学报》
CAS
2008年第1期74-76,共3页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区自然科学基金资助项目(2005年
项目批准号200521116)
