摘要
微波辐射下,由硫氰酸铵与α-氨基酸通过两步反应合成了11种5-取代-2-硫代海因衍生物,并用1HNMR,IR和元素分析确证了中间产物和终产物的结构.对比常规加热方法,微波辐射具有反应时间短(4min),每步反应产率高(85%～93%)的优点.同时对合成化合物2h的反应历程进行了讨论.
Eleven 5-substituted-2-thiohydantoin derivatives were synthesized by a two-step reaction of ammonium thiocyanate with a-amino acids under microwave irradiation. The structures of intermediate products and final products were characterized by 1H NMR, IR spectra and elemental analysis. Compared with conventional heating method, microwave irradiation possessed such advantages as short reaction time （4 min）, high yield of each step （85%-93%）. In the meantime, the reaction course of synthesis of compound 2h was discussed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第2期228-233,共6页
Chinese Journal of Organic Chemistry
基金
国家重点基础研究发展计划(973计划)(No.2003CB7160004)资助项目
